ABSTRACT
Primary intrahepatic stone （PIS）is one of the intractable diseases in hepatobiliary surgery and an important cause of death from benign biliary tract diseases, and it has a high prevalence in the Yangtze River basin and southeastern coastal areas of China. At present, the mechanism of PIS occurrence has not been fully elucidated, but the role of biliary flora in the formation of PIS has been recognized by more and more studies. This article reviews the research progress of biliary flora in the formation of PIS with a view to strengthening the clinical understanding of mechanism of PIS, increasing the attention to the detection of biliary flora, and providing a reference for the prevention and treatment of PIS and the improvement of prognosis.
ABSTRACT
Primary intrahepatic stones (PIS) is a refractory disease with a high incidence rate in southwest China, and some patients still require surgery again or even more times after initial treatment. Many studies in recent years have shown that some specific flora can colonize in the intrahepatic bile duct, leading to chronic infection and inflammation of the biliary system, and these specific types of flora, called "stone-causing flora", can produce metabolites such as β-glucuronidase and play an important role in the formation of pigmented stones. This article analyzes the role of stone-causing flora in the pathogenesis of PIS, so as to provide more treatment options for PIS patients.
ABSTRACT
Objective To study the clinical therapeutic effectiveness on primary intrahepatic stones(PIS) treated by Ursodeoxycholic Acid(UDCA) combined with Xiaoyao San.Methods 90 cases of patients with PIS were randomly divided into two groups:the therapeutic group(n=60) and control group(n=30).The therapeutic group treated by UDCA combined with Xiaoyao San for 45 days.And the control group treated by UDCA alone.Then we observed the changes of symptoms as well as B-ultrasonic examine.Results The total effective rate was 86.7% in therapeutic group,higher than that in the control group,60%(P